Santa Fe return to home soil to face Independiente Medellin at 10:10 PM Mar 23, 2026 in what could be a turning point in their Primera A – Apertura campaign.

Santa Fe are under pressure to rediscover form after a difficult run. Independiente Medellin will be hoping to turn things around after a tough stretch.

Historically, Santa Fe hold the edge with 3 wins to Independiente Medellin's 2 in 10 meetings. 4 of those have ended in draws. Their most recent meeting saw they last drew undefined-undefined.

With so much at stake in the Primera A – Apertura, both teams will be eager to leave their mark. Fine margins could decide this contest.